The general objective of this degree work is the documentary design of an Occupational Health and Safety Management System for the company GENHOSPI SAS, in compliance with the provisions of Decree 1072 of 2015, in order to prevent accidents of work and occupational diseases, thus contributing to a continuous improvement in terms of the productivity of the company, the reduction of accidents and absenteeism from work. In order to fulfill the main purpose of the work, an Initial diagnosis was made regarding safety and health at work, through information collection instruments applied to the company's personnel, with the results, the objectives, methodology and structure of the System were established. of Occupational Health and Safety Management. Using the Colombia Technical Guide, GTC 45 continues the investigation team with the identification of risks and dangers present in the company; The structural design of the Occupational Health and Safety Management System was then proceeded with the requirements and guidelines required in current regulations in Colombia under the Deming PHVA cycle, and finally, the necessary documentation was prepared for subsequent implementation and execution of the system by the company.